Blar i NTNU Open på forfatter "Marwarha, Gurdeep"
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Effects of doxorubicin on cell death and the transcriptome in human AC16 cardiomyocytes
Lunde, Ingvild (Master thesis, 2022)Bakgrunn: Kreft og hjarte- og karsjukdom er leiande dødsårsaker i verda. Doxorubicin er mykje nytta som cellegift i kreftbehandling, men utvikling av kardiotoksisitet avgrensar bruken. Faktorar som bidreg til doxorubicin-indusert ... -
Effects of overexpressing NOR-1 on cell death and cell viability in human cardiomyocytes during doxorubicin-induced stress
Berg, Per-Christian (Master thesis, 2021)Koronar hjertesykdom er den ledende dødsårsaken i verden, karakterisert av redusert blodforsyning til hjertet. Ubehandlet kan dette føre til en fullstendig blokkering av koronararteriene, kjent som et hjerteinfarkt. ... -
GSK3β Inhibition Is the Molecular Pivot That Underlies the Mir-210-Induced Attenuation of Intrinsic Apoptosis Cascade during Hypoxia
Marwarha, Gurdeep; Røsand, Øystein; Slagsvold, Katrine Hordnes; Høydal, Morten (Peer reviewed; Journal article, 2022)Apoptotic cell death is a deleterious consequence of hypoxia-induced cellular stress. The master hypoxamiR, microRNA-210 (miR-210), is considered the primary driver of the cellular response to hypoxia stress. We have ... -
miR-210 Regulates Apoptotic Cell Death during Cellular Hypoxia and Reoxygenation in a Diametrically Opposite Manner
Marwarha, Gurdeep; Røsand, Øystein; Scrimgeour, Nathan Robert; Slagsvold, Katrine Hordnes; Høydal, Morten (Peer reviewed; Journal article, 2021)Apoptotic cell death of cardiomyocytes is a characteristic hallmark of ischemia–reperfusion (I/R) injury. The master hypoxamiR, microRNA-210 (miR-210), is considered the primary driver of the cellular response to hypoxic ... -
NOR-1 overexpression protects AC16 human cardiomyocytes against cellular stress responses occurring during hypoxia
Hansson, Åse Mari Larsen (Master thesis, 2021)Bakgrunn: Det er vist at trening kan beskytte hjertet mot skader forårsaket av iskemi/reperfusjon (IR), men de underliggende cellulære mekanismene bak denne beskyttende effekten er fortsatt ukjent. Et av proteinene som er ... -
Overexpression of neuron-derived orphan receptor 1 (NOR-1) rescues cardiomyocytes from cell death and improves viability after doxorubicin induced stress
Berg, Per-Christian; Hansson, Åse Mari Larsen; Røsand, Øystein; Marwarha, Gurdeep; Høydal, Morten (Peer reviewed; Journal article, 2021)Following myocardial infarction, reperfusion injury (RI) is commonly observed due to the excessive formation of, e.g., reactive oxygen species (ROS). Doxorubicin (DOX), a widely used anti-cancer drug, is also known to cause ...